Highly selective and sensitive detection of cardiac troponin I (cTnI) is a powerful complement to clinical diagnosis of acute myocardial infarction (AMI). In this study, a strategy for cTnI detection was developed by constructing a universal biosensing interface composed of zwitterionic peptides and aptamers. The peptides were self-assembled onto gold chips, and some of them were biotinylated. The cTnI-specific binding aptamers were immobilized through the streptavidin-biotin system. Surface plasmon resonance (SPR) measurements revealed the preparation process. The developed aptasensor presents a linear detection with cTnI ranging from 20 ng/ml to 600 ng/ml and a detection limit of 20 ng/ml. The high immobilization of the aptamer enhances the sensitivity of the aptasensor and the calculated KD was 6.75 nM. Due to the outstanding antifouling property of the zwitterionic peptide, the developed aptasensor possesses a high resistance towards protein fouling. Moreover, the aptasensor has excellent selectivity and specificity towards cTnI in complex media. Hence, the proposed peptide-based aptasensor shows great potential for practical application in medium sized Myocardial Infarction (MI).
World Health Organization. Global status report on noncommunicable diseases 2014 [R]. World Health Organization, 2014.
Agewall S, Giannitsis E, Jernberg T, Katus H. Troponin elevation in coronary vs. non-coronary disease. Eur Heart J. 2010; 32: 404-411. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21169615
Wang J, Wang X, Ren L, Wang Q, Li L, et al. Conjugation of biomolecules with magnetic protein microspheres for the assay of early biomarkers associated with acute myocardial infarction. Anal Chem. 2009; 81: 6210R-6217. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19555077
Bottenus D, Jubery T Z, Ouyang Y, Dong WJ, Dutta P, et al. 10000-fold concentration increase of the biomarker cardiac troponin I in a reducing union microfluidic chip using cationic isotachophoresis. Lab Chip. 2011; 11: 890-898. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21416810
Leisy PJ, Coeytaux RR, Wagner GS, Chung EH, McBroom AJ, et al. ECG-based signal analysis technologies for evaluating patients with acute coronary syndrome: A systematic review. J Electrocardiol. 2013; 46: 92-97. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23273746
Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). J American College of Cardiology. 2018; 72: 2231-2264.
Bax J J, Baumgartner H, Ceconi C, Simoons ML, Chaitman BR, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol. 2012; 60: 1581-1598. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22958960
Collinson PO, Heung YM, Gaze D, Boa F, Senior R, et al. Influence of population selection on the 99th percentile reference value for cardiac troponin assays. Clin Chem. 2012; 58: 219-225. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22100808
Thygesen K, Mair J, Giannitsis E, Mueller C, Lindahl B, et al. How to use high-sensitivity cardiac troponins in acute cardiac care. Eur Heart J. 2012; 33: 2252-2257. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22723599
Jaffe A S, Ordonez-Llanos J. High sensitivity troponin in chest pain and acute coronary syndromes. A step forward?. Rev Esp Cardiol. 2010; 63: 763-769. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20609309
Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction. Clin Chem. 1992; 38: 2203-2214. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1424112
Adams 3rd J E, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, et al. Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation. 1993; 88: 101-106. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8319322
Bahadır EB, Sezgintürk MK. Applications of electrochemical immunosensors for early clinical diagnostics. Talanta. 2015; 132: 162-174. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25476294
Mann D L, Zipes D P, Libby P, et al. Braunwald's heart disease e-book: a textbook of cardiovascular medicine. Elsevier Health Sciences. 2014
Reichlin T, Irfan A, Twerenbold R, Reiter M, Hochholzer W, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation. 2011; 124: 136-145. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21709058
Fathil MFM, Arshad MKM, Gopinath SCB, Hashim U, Adzhri R, et al. Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers. Biosens Bioelectron. 2015; 70: 209-220. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25841117
Qureshi A, Gurbuz Y, Niazi J H. Biosensors for cardiac biomarkers detection: A review. Sensors and Actuators B: Chemical. 2012; 171: 62-76.
Cheng Z, Wang R, Xing YI, Zhao L , Choo J, et al. SERS-based immunoassay using gold-patterned array chips for rapid and sensitive detection of dual cardiac biomarkers. Analyst. 2019; 144: 6533-6540. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31553332
Dutra RF, Mendes RK, da Silva VL, Kubota LT. Surface plasmon resonance immunosensor for human cardiac troponin T based on self-assembled monolayer. J Pharm Biomed Anal. 2007; 43: 1744-1750. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17254730
Oh BK, Kim YK, Lee W, Bae YM, Lee WH, et al. Immunosensor for detection of Legionella pneumophila using surface plasmon resonance. Biosens Bioelectron. 2003; 18: 605-611. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12706569
Wu Q, Li S, Sun Y, et al. Hollow gold nanoparticle-enhanced SPR based sandwich immunoassay for human cardiac troponin I. Microchimica Acta. 2017; 184: 2395-2402.
Yang CT, Wu L, Liu X, Tran NT, Bai P, et al. Exploiting surface-plasmon-enhanced light scattering for the design of ultrasensitive biosensing modality. Anal Chem. 2016; 88: 11924-11930. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27934101
Guo Z, Gu C, Fan X, Bian Z, Wu H, et al. Fabrication of anti-human cardiac troponin I immunogold nanorods for sensing acute myocardial damage. Nanoscale Res Lett. 2009; 4: 1428-1433. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20652133
Sun C, Han Q, Wang D, Xu W, Wang W, et al. A label-free and high sensitive aptamer biosensor based on hyperbranched polyester microspheres for thrombin detection. Anal Chim Acta. 2014; 850: 33-40. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25441157
Dhawan S, Sadanandan S, Haridas V, Voelcker NH, Prieto-Simón B. Novel peptidylated surfaces for interference-free electrochemical detection of cardiac troponin I. Biosens Bioelectron. 2018; 99: 486-492. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28823973
Ko S, Kim B, Jo SS, Oh SY, Park JK. Electrochemical detection of cardiac troponin I using a microchip with the surface-functionalized poly (dimethylsiloxane) channel. Biosens Bioelectron. 2007; 23: 51-59. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17462876
Doehrman SR. Psycho-social aspects of recovery from coronary heart disease: a review. Soc Sci Med. 1977; 11: 199-218.
Gesellchen F, Zimmermann B, Herberg FW. Direct optical detection of protein-ligand interactions. Methods Mol Biol. 2005; 305: 17-45.
Hwang SY, Yoon CH, Jeon JY, et al. Quantitative assay of hepatitis B surface antigen by using surface plasmon resonance biosensor. Biotechnology and Bioprocess Engineering. 2005; 10: 309.
Mir M, Cameron PJ, Zhong X, Azzaroni O, Alvarez M, et al. Anti-fouling characteristics of surface-confined oligonucleotide strands bioconjugated on streptavidin platforms in the presence of nanomaterials. Talanta. 2009; 78: 1102-1106. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19269478
Wang Y, Cui M, Jiao M, Luo X. Antifouling and ultrasensitive biosensing interface based on self-assembled peptide and aptamer on macroporous gold for electrochemical detection of immunoglobulin E in serum. Anal Bioanal Chem. 2018; 410: 5871-5878. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29938372
Wolf M, Juncker D, Michel B, Hunziker P, Delamarche E. Simultaneous detection of C-reactive protein and other cardiac markers in human plasma using micromosaic immunoassays and self-regulating microfluidic networks. Biosens Bioelectron. 2004; 19: 1193-1202. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15046750
Bottenus D, Hossan MR, Ouyang Y, Dong WJ, Dutta P, et al. Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresis. Lab Chip. 2011; 11: 3793-3801. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21935555
Dorraj GS, Rassaee MJ, Latifi AM, Pishgoo B, Tavallaei M. Selection of DNA aptamers against Human Cardiac Troponin I for colorimetric sensor based dot blot application. J Biotechnol. 2015; 208: 80-86. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26003883
Negahdary M, Behjati-Ardakani M, Sattarahmady N, et al. Electrochemical aptasensing of human cardiac troponin I based on an array of gold nanodumbbells-Applied to early detection of myocardial infarction. Sensors and Actuators B: Chemical. 2017; 252: 62-71.
Ahirwar R, Nahar P. Development of an aptamer-affinity chromatography for efficient single step purification of Concanavalin A from Canavalia ensiformis. J Chromatogr B. 2015; 997: 105-109. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26102634
Wegner GJ, Wark AW, Lee HJ, Codner E, Saeki T, et al. Real-time surface plasmon resonance imaging measurements for the multiplexed determination of protein adsorption/desorption kinetics and surface enzymatic reactions on peptide microarrays. Anal Chem. 2004; 76: 5677-5684. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15456285
Zhang CG, Chang S J, Settu K, et al. High-sensitivity glycated hemoglobin (HbA1c) aptasensor in rapid-prototyping surface plasmon resonance[J]. Sensors and Actuators B: Chemical. 2019; 279: 267-273.
Jo H, Gu H, Jeon W, Youn H, Her J, et al. Electrochemical aptasensor of cardiac troponin I for the early diagnosis of acute myocardial infarction. Anal Chem. 2015; 87: 9869-9875. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26352249
Zhang CG, Chen CJ, Settu K, et al. Angle-Scanning Surface Plasmon Resonance System with 3D Printed Components for Biorecognition Investigation. Advances in Condensed Matter Physics. 2018; 2018.
Nowinski AK, Sun F, White AD, Keefe AJ, Jiang S. Sequence, structure, and function of peptide self-assembled monolayers. J Am Chem Soc. 2012; 134: 6000-6005. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22401132
Anker JN, Hall WP, Lyandres O, et al. Biosensing with plasmonic nanosensors[M]//Nanoscience and Technology: A Collection of Reviews from Nature Journals. 2010; 308-319.
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Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024: doi: 10.29328/journal.acr.1001099; 8: 075-077
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H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
Denis Tonini, Kai Wu, Renata Saha and Jian-Ping Wang*Denis Tonini,Kai Wu,Renata Saha,Jian-Ping Wang*. Feasibility study of magnetic sensing for detecting single-neuron action potentials. Ann Biomed Sci Eng. 2022 doi: 10.29328/journal.abse.1001018; 6: 019-029
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“Mobile apps and wearable technology are becoming ubiquitous in our environment. Their integration with healthcare delivery is just beginning to take shape. The early results are promising and the possibilities great."
BS, PharmD., MBA, CPHIMS, FHIMSS, Adjunct Professor, Global Healthcare Management, MCPHS University, Chief Strategy Offi cer, MedicaSoft, Senior Advisor, National Health IT (NHIT) Collaborative for Underserved, New York HIMSS, National Liaison, Health 2.0 Boston, Past Chair, Chair Innovation, USA
Helen Figge
“The choice to submit the forensic case study to the Journal of Addiction Therapy and Research was dictated by the match between the content and the potential readership. The publication process proved to be expedient and we were provided with constructive feedback from reviewers. The final article layout is attractive and conforms to standards. All-in-all, it has been a rewarding process.”
Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA
Elisabeth H. Wiig
The service is nice and the time of processing the application is fast.
Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong
Long Ching
Your service is very good and fast reply, Also your service understand our situation and support us to publication our articles.
Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine
Ayman M Abu Mustafa
“It was a delightful experience publishing my manuscript with the Clinical Journal of Obstetrics and Gynecology. They offered me lots of opportunities I never had from most publishing houses and their prompt services are greatly appreciated.”
Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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